First, let’s take a look at precisely what keeps cancer cells alive, then we will return and take a look at how the cannabinoids CBD (cannabidiol) and THC (tetrahydrocannabinol) deciphers cancer’s aliveness.
In every cell, there is a household of interconvertible sphingolipids that mainly handle the life and death of that cell. This profile of aspects is called the “Sphingolipid Rheostat.” If endogenous ceramide( a signaling metabolite of sphingosine-1-phosphate) is high, then cell death (apoptosis) impends. If ceramide is low, the cell is strong in its vigor.
Exceptionally, when THC links to the CB1 or CB2 cannabinoid receptor website on the cancer cell, it triggers a boost in ceramide synthesis which owns cell death. A regular healthy cell does not produce ceramide in the existence of THC, therefore is not impacted by the cannabinoid.
How Does The Cancer Die?
The cancer cell passes away, not since of cytotoxic chemicals, however, because of a small little shift in the mitochondria. Within a lot of cells, there is a cell nucleus, many mitochondria (hundreds to thousands), and different other organelles in the cytoplasm. The function of the mitochondria is to produce energy (ATP) for cell usage. As ceramide begins to collect, showing up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, an essential protein in energy synthesis. Cytochrome c is pressed out of the mitochondria, eliminating the source of energy for the cell.
Ceramide likewise triggers genotoxic tension in the cancer cell nucleus producing a protein called p53, whose task it is to interfere with calcium metabolic process in the mitochondria. If this weren’t enough, ceramide interferes with the cellular lysosome, the cell’s digestion system that offers nutrients for all cell functions. Ceramide, and other sphingolipids, actively prevent pro-survival paths in the cell leaving no possibility at all of the cancer cell survival.
The secret to this procedure is the build-up of ceramide in the system. This implies taking restorative quantities of CBD and THC, progressively, over a period, keeping the metabolic pressure on this cancer cell death path.
CBD Oil Continues To Kill Cancer Cells…
How did this path happen? Why is it that the body can take a natural plant enzyme and utilize it for lengthy recovery in various physiological systems? This endocannabinoid system exists in all animal life, merely awaiting its matched exocannabinoid activator. This is intriguing. Our endocannabinoid system covers all cells and nerves; it is the messenger of info streaming in between our body immune system and the central nerve system (CNS). It is accountable for neuroprotection and micro-manages the body immune system. This is the primary control system that preserves homeostasis; our well being.
Out of interest, how does the work get done at the cellular level, and where does the body make the endocannabinoids? Here we see that endocannabinoids have their origin in afferent neuron right at the synapse. When the body is jeopardized through disease or injury, it calls insistently to the endocannabinoid system and directs the body immune system to bring recovery. If these homeostatic systems are deteriorated, it ought to be not a surprise that exocannabinoids are restorative. It assists the body in the most natural method possible.
How Does the CBD Work?
To see how this works we imagine the cannabinoid as a three dimensional particle, where one part of the particle is set up to fit the nerve or immune cell receptor website much like a type of a lock. There are at least two kinds of cannabinoid receptor websites, CB1 (CNS) and CB2 (immune). In basic, CB1 triggers the CNS messaging system, and CB2 triggers the body immune system. However, it’s a lot more complicated than this. Both THC and anandamide trigger both receptor websites. Other cannabinoids trigger one or the other receptor websites. Amongst the stress of Cannabis, C. sativa tends towards the CB1 receptor, and C. indica tends towards CB2. So sativa is more neuroactive, and indica is more immunoactive. Another element here is that sativa is controlled by THC cannabinoids, and indica is predominately CBD (cannabidiol).
It is understood that THC and CBD are biomimetic to anandamide, that is, the body can utilize both interchangeably. Therefore, when tension, injury, or disease need more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids are triggered. If the stress is temporal, then the treatment can be mundane. If the need is continual, such as in cancer, then treatment has to supply regular pressure of the regulating representative on the homeostatic systems.
Usually, CBD gravitates to the mostly jam-packed CB2 receptors in the spleen, the home of the body’s body immune system. From there, immune cells look for and damage cancer cells. Surprisingly, it has been revealed that THC and CBD cannabinoids can eliminate cancer cells straight without going through immune intermediaries. THC and CBD pirate the lipoxygenase path to straight prevent tumor development. As a side note, it has been found that CBD hinders anandamide reuptake. Here we see that cannabidiol assists the body to protect its natural endocannabinoid by impeding the enzyme that breaks down anandamide.
This quick study touches gently on a couple of important principles. Primarily I want to leave you with gratitude that nature has developed the best medication that fits precisely with our own body immune system of receptors and signaling metabolites to offer fast and total immune action for systemic stability and metabolic homeostasis.